Figure 2 | Scientific Reports

Figure 2

From: Analysis of β-tubulin-carbendazim interaction reveals that binding site for MBC fungicides does not include residues involved in fungicide resistance

Figure 2

Structural comparison of the three-dimensional models of MBC-sensitive and MBC-resistant P. xanthii β-tubulin proteins. Compared to the MBC-sensitive β-tubulin protein (A), in the MBC-resistant β-tubulin (B) the E198A mutation results in the formation of additional β-strands (β8, β9, β10 and β11). (C and D) Superposition of MBC-sensitive (cyan) and MBC-resistant (gray) P. xanthii β-tubulin models. As observed, both models do not entirely superpose, indicating a conformational change resulting from the E198A substitution. This conformational change is not restricted to a specific protein domain; rather, it triggers a rearrangement of the entire protein structure.

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