Figure 7
From: Specific features of human monocytes activation by monophosphoryl lipid A
(A) Inhibition of TNF and IL-1β production by pan-caspase inhibitor (Z-VAD 20 µM) of human adherent mononuclear cells activated by either conventional smooth E. coli O111:B4 LPS (cLPS) (100 ng/ml), highly purified S. abortus equi LPS (hpLPS) (100 ng/ml), highly purified rough S. minnesota LPS (ReLPS) (100 ng/ml) or MPLA (1 µg/ml) for different donors. (B) Similar experiments performed in the presence of IL-1Ra (100 µg/ml). Each dot represents one individual donor. Neither Z-VAD nor IL-1Ra affected the cytokine production in the absence of agonists (data not shown). Results are expressed as percent of the individual responses in the absence of inhibitors. *p < 0.5; **p < 0.01; ***p < 0.001; ****p < 0.0001.
