Figure 9
From: Specific features of human monocytes activation by monophosphoryl lipid A
Effect of Syk inhibitor R406 (A) 1 µM, or (B) 5 µM on TNF and IL-1β production by human adherent mononuclear cells activated by either conventional smooth E. coli O111:B4 LPS (cLPS) (100 ng/ml), highly purified S. abortus equi LPS (hpLPS) (100 ng/ml), highly purified rough S. minnesota LPS (ReLPS) (100 ng/ml), MPLA (1 µg/ml) or zymosan depleted (100 µg/ml) for different donors. R406 did not affect the cytokine production in the absence of agonists (data not shown). Each dot represents one individual donor. Results are expressed as percent of the individual responses in the absence of inhibitor. *p ≤ 0.5; **p < 0.01; ****p < 0.001; ***p < 0.0001.
