Figure 4
From: Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways
Changes in constrictor force and reactivity in response to muscarine in various airway segments from cav-3+/+ (WT) and cav-3−/− (KO) mice. Tension changes were measured in force [grams]. After equilibration, baseline tension was always accustomed to 0.5 g. Baseline was set as 100% and the maximum response at each concentration was evaluated. Each point represents the mean number of animals (n) ± SEM. (a,b) Concentration-dependent contraction of ASM was induced by muscarine in cav-3+/+ (a) and cav-3−/− (b) mouse strains. All sigmoidal concentration-response curves shown here were plotted according to the Hill equation. (a’-b’) Depicted is the constrictor force of different tracheal parts and extrapulmonary bronchi in cav-3+/+ (a’) and cav-3−/− (b’) mice. No difference in maximal responses (Emax, a” and b”) and pEC50 (a”’ and b”’) values was observed in cav3+/+ and cav3−/− mice between tracheal parts or bronchi when data were analyzed by One-Way ANOVA and subjected to Dunnett’s multiple comparisons test afterwards.
