Figure 5
From: Caveolin-3 differentially orchestrates cholinergic and serotonergic constriction of murine airways
Comparison of force and reactivity in response to muscarine between cav-3+/+ (WT) and cav-3−/− (KO) mice. For each individual experiment the maximal responses (Emax) and pEC50 values for muscarine in force level (a–d) and airway reactivity (a’–d’) were estimated. All sigmoidal concentration-response curves were plotted according to the Hill equation. (a’–d’) The airway reactivity represents the constrictor response to muscarine compared to the corresponding KCl response. All data were analyzed with the Student’s unpaired t-test. Each point is shown as the mean number of animals (n) ± SEM. There is no difference between the cav-3−/− and the cav-3+/+ airway segments with regards to reactivity level and contraction force.
