Figure 6 | Scientific Reports

Figure 6

From: LncRNA OIP5-AS1 is overexpressed in undifferentiated oral tumors and integrated analysis identifies as a downstream effector of stemness-associated transcription factors

Figure 6

Transactivation of OIP5-AS1 by stemness regulatory TFs and downstream molecular cascade. Stemness associated TFs transactivates OIP5-AS1 by binds to the promoter. The overexpressed OIP5-AS1 sponges the miRNAs targeting KMT2A, KMT2C and CELF1. With deficient in post-transcriptional regulation, KMT2A, KMT2C and CELF1 overexpress resulting in chromatin modification and increased mRNA stability and active translation specific mRNAs. OIP5-AS1 in addition activates co-expression of NEAT1, TUG1 and HOTAIR which sponges stemness regulatory miR-143/145 and maintains the steady state level of stemness TFs. Further, in cis NEAT1, TUG1 and HOTAIR can bind to open chromatins facilitating the binding of KMT2A and KMT2C along with other chromatin modifying enzymes to modify methylation signature and enables active transcription of the genes in the euchromatin sites. The sponging of miR-143/145 also facilitates the overexpression of OIP5 mRNA.

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