Figure 2 | Scientific Reports

Figure 2

From: Colon Cancer-Upregulated Long Non-Coding RNA lincDUSP Regulates Cell Cycle Genes and Potentiates Resistance to Apoptosis

Figure 2

Knockdown of lincDUSP reduces proliferation and colony formation in vitro. (A,B) Verification of lincDUSP knockdown in V703 and V481 cells by LNA GapmeRs at 24, 48, and 72 hours. Error bars = SD (n = 2). (C,D) Proliferation assay in V703 and V481 cells treated with control GapmeRs vs. lincDUSP GapmeRs. The knockdown of lincDUSP significantly affects cell proliferations as compared to control cells. (E,F) Colony formation assay in V703 and V481 cells treated with control GapmeRs vs. lincDUSP GapmeRs. The depletion of lincDUSP has significant effects on the clonogenic capacity of colon cancer cells. Representative images shown below graph. Asterisks denote significant difference vs. negative control GapmeR by two-tailed t-test. **<0.05; ***<0.01.

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