Table 3 Parameters of organ function of the study groups during the 24-hour interventional period.

From: Comparison of first-line and second-line terlipressin versus sole norepinephrine in fulminant ovine septic shock

Variable

Group

Shock time

4 h

8 h

16 h

24 h

Lactate [mmol·L−1]

Control

1.8 [1.8; 1.9]

2.7 [2.4; 3.0]

2.9 [2.5; 3.2]

2.9 [2.7; 3.2]

2.2 [1.8; 3.8]

TP first-line

1.9 [1.9; 2.0]

3.3 [3.1; 3.5]

3.6 [2.9; 3.9]

3.3 [2.3; 3.5]

2.6 [2.5; 3.2]

TP second-line

1.8 [1.8; 2.2]

2.6 [2.2; 2.9]

2.6 [2.3; 3.5]

2.8 [2.1; 4.7]

3.3 [3.1; 3.6]

Creatinine [mmol·L−1]

Control

1.5 [1.2; 1.7]

1.1 [0.9; 1.2]

1.2 [1; 1.4]

1.1 [0.9; 1.7]

1.3 [1.1; 2.3]

TP first-line

1.8 [1.3; 1.9]

1.4 [1.1; 1.8]

1.5 [1.1; 1.6]

2.2 [0.9; 2.3]

2.1 [1.2; 2.5]

TP second-line

1.3 [1.2; 2.0]

1.1 [0.8; 1.2]

1.4 [0.8; 1.6]

1.6 [1.3; 2.0]

1.9 [1.6; 2.6]

Crea- Clearance [mL·min-1·m−2]

Control

11 [4; 39]

55 [34; 73]

65 [43; 69]

32 [10; 53]

14 [9; 22]

TP first-line

0 [0; 8]

60 [41; 83]

41 [21, 68]

55 [25; 55]

4 [0; 36]

TP second-line

3 [0; 9]

61 [40; 96]

50 [21; 70]

16 [6; 36]

0 [0; 18]

Diuresis [mL·kg−1·h−1]

Control

0.1 [0.1; 0.4]

0.9 [0.5; 1.6]

0.5 [0.2; 1.0]

0.6 [0.2; 1.2]

0.6 [0.3; 0.9]

TP first-line

0 [0; 0.1]

1.2 [0.7; 2.4]

0.3 [0; 0.7]

0.4 [0.4; 0.6]

0.1 [0; 0.3]

TP second-line

0.1 [0; 0.1]

0.8 [0.7; 2.0]

0.3 [0.2; 0.5]

0.4 [0.3; 0.6]

0.2 [0; 0.4]

Bilirubin [mg·dL−1]

Control

0.1 [0.1; 0.8]

0.1[0.1; 0.1]

0.1 [0.1; 0.1]

0.1 [0.1; 0.1]

0.1 [0.1; 0.1]

TP first-line

0.1 [0.1; 0.1]

n.a.

0.1 [0.1; 0.1]

0.1 [0.1; 0.1]

0.1 [0.1; 0.1]

TP second-line

0.1 [0.1; 0.1]

0.1 [0.1; 0.8]

0.1 [0.1; 0.1]

0.1 [0.1; 0.2]

0.1 [0.1; 0.1]

Protein [g·dL−1]

Control

4.1 [3.9; 4.5]

1.9 [1.4; 2.3]

1.5 [1.0; 1.9]

1.1 [0.8; 1.7]

1.4 [1.4; 1.5]

TP first-line

4.3 [4.1; 5.0]

1.8 [1.5; 2.5]

1.3 [1.1; 1.9]

1.8 [1.0; 1.9]

1.9 [1.3; 2.0]

TP second-line

4.6 [4.1; 5.1]

1.9 [1.5; 2.3]

1.3 [1.1; 1.8]

1.3 [1.2; 1.8]

1.4 [1.3; 1.8]

Arginine vasopressin [pg·mL−1]

Control

239 [195; 291]

8 [5; 12]

11 [3; 96]

9 [4; 19]

9 [8; 14]

TP first-line

104 [30; 163]

5 [4; 10]

8 [4; 28]

15 [3; 20]

10 [8; 15]

TP second-line

257 [190; 273]

6 [4; 24]

12 [5; 20]

16 [12; 25]

25 [8; 40]

  1. Values are presented as median [interquartile range].
  2. Bilirubin, serum bilirubin concentration; Crea-Clearance, creatinine clearance; Creatinine, serum creatinine concentration; Protein, serum protein concentration; TP, Terlipressin.
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