Table 2 Clinical Outcomes of Treg cell infusion within renal transplant recipients.

From: A Phase I Clinical Trial with Ex Vivo Expanded Recipient Regulatory T cells in Living Donor Kidney Transplants

Subject #

Date of

Cell # Administered (×109)

Biopsy at

DSA at

Graft loss at

Transplant

Treg infusion

3 months

1 year

3 months

1 year

2 years

1 year

2 years

1

7/10/14

9/8/2014

0.5

NR

NR

−

+

+

NO

NO*

2

8/7/14

10/6/2014

0.5

NR

NR

−

−

−

NO

NO

3

8/29/14

10/28/2014

0.5

NR

NR

−

−

−

NO

NO

4

9/22/14

11/21/2014

1.0

NR

NR

−

−

−

NO

NO

5

12/4/14

2/2/2015

1.0

NR

NR

−

−

−

NO

NO

6

1/8/15

3/9/2015

1.0

NR

NR

−

−

−

NO

NO

7

2/2/2015

4/3/2015

5.0

NR

NR

−

−

−

NO

NO

8

3/27/2015

5/26/2015

5.0

NR

SCR C4d+

−

+

+

NO

NO

9

4/23/2015

6/22/2015

5.0

NR

NR

−

−

−

NO

NO

  1. (NR) defined as no rejection;
  2. (SCR) defined as subclinical rejection with C4d+ staining on biopsy.
  3. (DSA) defined as donor specific antibodies.
  4. *Developed recurrence of original disease in second year post transplant.