Table 2 Metaanalysis of the association of the 24 SNPs with response to MTX assessed as ΔDAS28 at 6 months in the four populations of RA patients.

Locus	SNP	MA	Fixed effects		Heterogeneity		Random effects
Locus	SNP	MA	β (SE)	P	I²	P	β (SE)	P
Candidate gene
ABCB1	rs1045642	A	0.02 (0.04)	0.6	28	0.2	0.02 (0.05)	0.7
ABCC1	rs35592	C	0.03 (0.05)	0.6	71	0.02	−0.04 (0.10)	0.7
AMPD1	rs17602729	A	−0.11 (0.07)	0.10	61	0.05	−0.17 (0.12)	0.15
ATIC	rs4673990	G	0.08 (0.04)	0.07	6	0.4	0.08 (0.05)	0.09
	rs12995526	A	0.04 (0.04)	0.4	36	0.2	0.02 (0.06)	0.7
	rs16853834	T	0.04 (0.06)	0.6	11	0.3	0.04 (0.07)	0.6
	rs2372536	G	0.07 (0.05)	0.1	17	0.3	0.07 (0.06)	0.2
ITPA	rs2295553	C	0.09 (0.04)	0.040	0	0.6	0.09 (0.04)	0.040
	rs1127354	A	0.07 (0.09)	0.4	19	0.3	0.06 (0.10)	0.5
MTRR	rs1801394	A	−0.14 (0.04)	0.0016	24	0.3	−0.15 (0.05)	0.0056
MTHFD1	rs2236225	A	−0.06 (0.05)	0.2	0	0.8	−0.06 (0.05)	0.2
SLC46A1	rs2239907	T	−0.01 (0.04)	0.7	0	0.6	−0.01 (0.04)	0.7
TYMS	rs699517	T	−0.03 (0.05)	0.5	57	0.07	0.00 (0.08)	1.0
GWAS hit
ARL14/PPM1L	rs7624766	G	−0.03 (0.05)	0.5	0	0.5	−0.03 (0.05)	0.5
BMP2	rs2650972	T	−0.04 (0.04)	0.4	0	0.8	−0.04 (0.04)	0.4
DHFR	rs5836788	del	−0.01 (0.05)	0.8	0	0.5	−0.01 (0.05)	0.8
10p15.1	rs1901633	G	0.05 (0.05)	0.3	0	0.7	0.05 (0.05)	0.3
14q13.1	rs4982133	A	−0.06 (0.05)	0.3	0	1.0	−0.06 (0.05)	0.3
15q26.2	rs1703794	C	−0.01 (0.05)	0.8	0	0.4	−0.01 (0.05)	0.8
20q13	rs6064463	C	−0.06 (0.05)	0.2	11	0.3	−0.06 (0.05)	0.3
MTRR	rs162040	C	−0.07 (0.06)	0.3	60	0.06	−0.07 (0.11)	0.5
PTPRM	rs6506569	C	0.02 (0.05)	0.6	0	0.8	0.02 (0.05)	0.6
TYMS	rs2244500	G	0.02 (0.05)	0.6	64	0.04	0.07 (0.09)	0.4
	rs2847153	A	0.02 (0.06)	0.7	0	0.5	0.02 (0.06)	0.7

Summary regression coefficients (β) and their standard errors (SE) obtained with fixed effects and random effects metaanalysis are presented together with the inconsistency (I²) and P value of the Cochran Q test for heterogeneity. Multivariate linear regression in each population included sex, age, baseline DAS28, previous use of DMARD and concomitant treatment with corticosteroids.

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