Table 3 Metaanalysis of the association of the 24 SNPs with response to MTX according to the EULAR criteria at 6 months in the four populations of RA patients.

From: Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis

Locus

SNP

MA

Fixed effects

Heterogeneity

Random effects

OR (95% CI)

P

I2

P

OR (95% CI)

P

Candidate gene

   ABCB1

rs1045642

A

0.95 (0.8–1.2)

0.6

22

0.3

0.97 (0.7–1.2)

0.8

   ABCC1

rs35592

C

1.19 (0.9–1.5)

0.2

61

0.05

1.24 (0.8–1.9)

0.3

   AMPD1

rs17602729

A

1.08 (0.8–1.5)

0.6

42

0.2

1.14 (0.7–1.8)

0.6

   ATIC

rs4673990

G

0.73 (0.6–0.9)

0.009

0

0.5

0.73 (0.6–0.9)

0.009

 

rs12995526

A

0.85 (0.7–1.1)

0.1

52

0.10

0.86 (0.6–1.2)

0.4

 

rs16853834

T

0.91 (0.7–1.3)

0.6

0

0.5

0.91 (0.7–1.3)

0.6

 

rs2372536

G

0.72 (0.6–0.9)

0.009

8

0.4

0.72 (0.6–0.9)

0.014

   ITPA

rs2295553

C

0.81 (0.6–1.02)

0.1

0

1.0

0.81 (0.6–1.02)

0.1

 

rs1127354

A

0.74 (0.5–1.1)

0.2

0

0.6

0.74 (0.5–1.1)

0.2

   MTRR

rs1801394

A

1.39 (1.1–1.8)

0.004

0

0.6

1.39 (1.1–1.8)

0.004

   MTHFD1

rs2236225

A

1.03 (0.8–1.3)

0.8

0

0.5

1.03 (0.8–1.3)

0.8

   SLC46A1

rs2239907

T

0.96 (0.8–1.2)

0.7

0

0.8

0.96 (0.8–1.2)

0.7

   TYMS

rs699517

T

1.03 (0.8–1.3)

0.8

0

0.6

1.03 (0.8–1.3)

0.8

GWAS hit

   ARL14/PPM1L

rs7624766

G

1.13 (0.9–1.4)

0.3

47

0.13

1.15 (0.8–1.6)

0.4

   BMP2

rs2650972

T

1.28 (1.02–1.6)

0.035

0

0.8

1.28 (1.02–1.6)

0.035

   DHFR

rs5836788

del

1.00 (0.8–1.3)

1.0

17

0.3

1.00 (0.8–1.3)

1.0

   10p15.1

rs1901633

G

0.88 (0.7–1.1)

0.3

0

0.9

0.88 (0.7–1.1)

0.3

   14q13.1

rs4982133

A

1.19 (0.9–1.6)

0.2

0

0.7

1.19 (0.9–1.6)

0.2

   15q26.2

rs1703794

C

1.12 (0.9–1.5)

0.4

5

0.4

1.12 (0.8–1.5)

0.4

   20q13

rs6064463

C

1.17 (0.9–1.5)

0.2

0

0.5

1.17 (0.9–1.5)

0.2

   MTRR

rs162040

C

1.35 (0.98–1.9)

0.1

0

1.0

1.35 (0.98–1.9)

0.1

   PTPRM

rs6506569

C

0.89 (0.7–1.1)

0.3

0

0.5

0.89 (0.7–1.1)

0.3

   TYMS

rs2244500

G

0.89 (0.7–1.1)

0.4

0

0.9

0.89 (0.7–1.1)

0.4

 

rs2847153

A

1.02 (0.8–1.4)

0.9

0

0.7

1.02 (0.8–1.4)

0.9

  1. Summary odds ratios (OR) and their confidence intervals (95% CI) obtained with fixed effects and random effects metaanalysis are presented together with the inconsistency (I2) and p value of the Cochran Q test for heterogeneity. Multivariate logistic regression in each population included sex, age, baseline DAS28, previous use of DMARD and concomitant treatment with corticosteroids.
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