Table 3 Predicted miR-92a target genes and their impact on atherosclerosis via PicTar.

From: MicroRNA expression profile of human advanced coronary atherosclerotic plaques

Gene symbol

Gene Name

Impact on Atherosclerosis

Reference (inter alia)

USF2

Upstream Transcription Factor 2

related to familial hypercholsteremia

Chen et al., 2014, Int J Mol Med.

MEF2D

Myocyte Enhancer Factor 2D

regulates proliferation of VSMCs

Zhao et al., 2002, Arch Biochem Biophys.

GDF11

Growth Differentiation Factor 11

protects against endothelial cell injury

Mei et al., 2016, Mol Ther.

RGS3

Regulator of G-protein Signalling 3

protects against pathological changes of adventitial fibrobloasts

Xu et al., 2017, Cell Biochem Funct.

KLF2

Kruppel-Like Factor 2

modulated endothelial homeostasis, vasoregulation, vascular growth/remodeling, and inflammation

Novodvorsky et al., 2014, Prog Mol Biol Transl Sci.

NADPH Oxidase

NicotinAmidadenindinucleotidPhosphat Oxidase

impact on vascular oxidative stress

Di Pietro et al., 2017, Int J Mol Sci.

TRAF3

Tumor necrosis factor Receptor-Associated Factor 3

modulates CD40 signaling in atherogenesis

Zirlik et al., 2007, Arterioscler Thromb Vasc Biol.

CD51

CD51

expressed on endothelial microparticles

Arteaga et al., 2006, Am J Cardiol.

GRK5

G protein-coupled Receptor Kinase-5

attenuates atherosclerosis by regulating receptor tyrosine kinases

Wu et al., 2012, Arterioscler Thromb Vasc Biol.

Adrenomedullin

adrenomedullin

marker of carotid plaques

Gottsäter et al., 2013, J Hypertens.

KLF4

Kruppel-Like Factor 2

promotes transition of VSMC phenotype

Shankman et al., 2015, Nat Med.

MYCBP2

Myc Binding Protein 2

suppresses M2-like phenotypes in macrophages

Pierre et al., 2017, Eur J Immunol.

RYR3

Ryanodine Receptor 3

RYR3 gene polymorphisms associates with atherosclerosis

Zhao et al., 2014, BMC Cardiovasc Disord.

CREB1

Cyclic adenosine monophosphate Response Element-Binding protein

enhances interleukin-17A production and inflammation

Kotla et al., 2013, Sci Signal.

COL1A2

Collagen 1A2

enhanced expression in human aortal intima during atherogenesis

Shchelkunova et al., 2013, Biochemistry (Mosc).

GATA6

GATA binding protein 6

regulates adehsion moleculaes in endothlial cells

Tsoyi et al., 2010, Atherosclerosis.

NFAT5

Nuclear Factor of Activated T-cells 5

drives macrophage migration

Halterman et al., 2012, Front Physiol.

ITR

Inotocin Receptor

enhances VSMC hyperplasia

Kang et al., 2015, PLoS One.

PKCε

Protein Kinase C epsilon

inflammation and smooth muscle cell dysfunction

Raghuraman et al., 2016, Atherosclerosis.

PAF-AH

Platelet-Activating Factor AcetylHydrolase

modulation of inflammation and plaque formation

Karabina et al., 2010, Biochimie