Figure 5
From: Hepatic stellate cells secrete Ccl5 to induce hepatocyte steatosis
Ccr5 specific inhibitor Maraviroc attenuates pro-steatotic effect of Ccl5 on hepatocytes. (A) Primary hepatocytes express Ccr5 at a level significantly higher than Ccr1 or Ccr3, measured with qPCR. (B,C) Ccr5 specific inhibitor Maraviroc attenuated pro-steatotic effect of Ccl5 on primary hepatocytes, the level of steatosis quantified with Bodipy stained area fraction. Data are presented as mean +/− SD (*P < 0.05 for comparisons among cells receiving 50 ng/ml of Ccl5; #P < 0.05 for comparisons among cells receiving 100 ng/ml of Ccl5). qHSC, quiescent hepatic stellate cell; Hep, hepatocyte; MVC, Maraviroc.
