Figure 2 | Scientific Reports

Figure 2

From: A workflow for the integrative transcriptomic description of molecular pathology and the suggestion of normalizing compounds, exemplified by Parkinson’s disease

Figure 2

Differential analysis of gene expression and sample clustering. (a) The heatmap of the expression patterns of the 116 identified dysregulated genes between the PD and the control cohorts. Blue spots represent down-regulation whereas red-yellow spots denote up-regulation patterns. The dendrograms on the upper and left sides show the hierarchical clustering tree of genes or samples. (b) The PCA clustering for the normalized gene expression samples. The two highlighted PD and control samples are incorrectly clustered to the corresponding cohort, however they had almost no impact on the analysis results when we excluded them. (c) The Log fold change (LFC) of the 24 dysregulated genes and the 3 dysregulated miRNAs, which are known to be highly associated with PD progression and pathways. Each colour refers to a different gene or miRNA. The heatmap and PCA clustering for miRNA samples are shown in Figure S1.

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