Table 1 Clinical characteristics of patients stratified by an estimated glomerular filtration rate (eGFR) of 60 ml/min/1.73 m2.

From: Synergistic effect of renalase and chronic kidney disease on endothelin-1 in patients with coronary artery disease ‒ a cross-sectional study

 

All

(N = 342)

eGFR <60

(N = 85)

eGFR ≥60

(N = 257)

P#

Demographic characteristics

 Age (year)

62 ± 11

69 ± 10

60 ± 11

<0.001

 Male, n (%)

304 (88.9%)

74 (87.1%)

230 (89.5%)

0.674

 Current smoker, n (%)

211 (61.7%)

46 (54.1%)

165 (64.2%)

0.126

 Hypertension, n (%)

325 (95.0%)

78 (91.8%)

247 (96.1%)

0.190

Anthropometric data

 BMI (kg/m2)

26.2 ± 3.7

25.8 ± 3.5

26.3 ± 3.8

0.264

 Waist circumference (cm)

91.5 ± 9.1

91.3 ± 8.8

91.5 ± 9.2

0.847

 Systolic blood pressure (mmHg)

128 ± 19

132 ± 19

126 ± 18

0.010

 Diastolic blood pressure (mmHg)

74 ± 10

73 ± 10

75 ± 11

0.324

Glucose/lipoprotein/CRP

 Fasting glucose (mmol/L)

5.4 ± 0.8

5.3 ± 1.0

5.4 ± 0.7

0.781

 Triglycerides (mmol/L)

1.5 ± 0.8

1.7 ± 1.1

1.4 ± 0.7

0.034

 Total cholesterol (mmol/L)

4.2 ± 1.0

4.3 ± 1.0

4.2 ± 1.0

0.825

 HDL cholesterol (mmol/L)

1.2 ± 0.3

1.2 ± 0.3

1.2 ± 0.3

0.554

 LDL cholesterol (mmol/L)

2.4 ± 0.9

2.4 ± 0.9

2.4 ± 0.9

0.834

 CRP (mg/L)*

2.5 ± 2.4

3.2 ± 2.7

2.3 ± 2.3

0.004

Renal function

 Albumin to creatinine ratio (mg/g)*

48 ± 152

96 ± 244

33 ± 101

<0.001

 eGFR (ml/min/1.73 m2)

73 ± 21

48 ± 11

82 ± 16

<0.001

Number of vessels displaying significant narrowing on coronary angiography

   

0.968

 No vessel but MI history, n (%)

38 (11.1%)

10 (11.8%)

28 (10.9%)

 

 One vessel, n (%)

127 (37.1%)

33 (38.8%)

94 (36.6%)

 

 Two vessels, n (%)

102 (29.8%)

24 (28.2%)

78 (30.4%)

 

 Three vessels, n (%)

75 (21.9%)

18 (21.2%)

57 (22.2%)

 

Cardiorenal factors

 Endothelin-1 (pg/ml)

1.70 ± 0.77

1.95 ± 0.77

1.62 ± 0.76

<0.001

 Renalase (ng/ml)

37.1 ± 13.3

46.8 ± 17.1

33.9 ± 9.9

<0.001

Current medications

 Antihypertensive agents, n (%)

317 (92.7%)

76 (89.4%)

241 (93.8%)

0.272

 ACE inhibitor or ARB, n (%)

229 (67.0%)

57 (67.1%)

172 (66.9%)

0.999

 α-blocker, n (%)

22 (6.4%)

6 (7.1%)

16 (6.2%)

0.987

 β-blocker, n (%)

102 (29.8%)

31 (36.5%)

71 (27.6%)

0.159

 Calcium channel blocker, n (%)

173 (50.6%)

42 (49.4%)

131 (51.0%)

0.901

 Diuretics, n (%)

60 (17.5%)

18 (21.2%)

42 (16.3%)

0.395

 Antiplatelet, n (%)

333 (97.4%)

81 (95.3%)

252 (98.1%)

0.323

 Statins, n (%)

257 (75.1%)

59 (69.4%)

198 (77.0%)

0.205

  1. ACE = angiotensin-converting enzyme, ARB = angiotensin II receptor blocker, BMI = body mass index, CRP = C-reactive protein, eGFR = estimated glomerular filtration rate, HDL = high-density lipoprotein, LDL = low-density lipoprotein, MI = myocardial infarction.
  2. *Values were logarithm-transformed (log) in the analyses due to a skewed distribution.
  3. #P values for differences between the two groups.
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