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Figure 1

From: Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis

Figure 1

eIF4G1 is over-expressed in multiple clinical cohorts of PCa: Analysis of eIF4G1 expression in PCa samples from different databases: (a) mRNA levels of eIF4G1 in Normal vs prostate tumor samples from TCGA dataset. (b) mRNA levels of eIF4G1 in Paired Normal vs prostate tumor samples from TCGA dataset. (c) A Graded increase in eIF4G1 with increasing Gleason Score (GS) (TCGA). (d) High expression of eIF4G1 decreases survival probability (TCGA data set, time in months). (e) eIF4G1 is amplified and overexpressed in 16% patients with Metastatic Prostate Cancer dataset. (f) eIF4G1 is amplified and overexpressed in 59% patients in CRPC-Neuroendocrine Prostate Cancer dataset, while no change is observed in eIF4E. p-values are indicated as *<0.05, **<0.01, ***<0.001.

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