Figure 4 | Scientific Reports

Figure 4

From: Eukaryotic Translation Initiation Factor 4 Gamma 1 (eIF4G1) is upregulated during Prostate cancer progression and modulates cell growth and metastasis

Figure 4

Knockdown of eIF4G1 reduces the levels of Cyclin D1, p-Rb, delays cell cycle and inhibitor of eIF4G complex impairs prostasphere formation: (a) Knockdown of eIF4G1 decreases Rb/p-Rb, Cyclin D1 protein levels and delays cells at the G0/G1 phase of cell cycle in LNCaP (a,b) and C4-2B (c,d). Adjacent is quantitation of cell cycle distribution in the different phase. (e). Representative images for prostasphere formation with control and treated with 5–10 µM of 4EGI-1 (eIF4G-eIF4E complex inhibitor) for LNCaP (e) and CRPC cells (C4-2B cells) (f).

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