Figure 7
From: Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin
Homotypic endothelial TNTs mediate Ca2+ propagation. Fluo-4 loaded HUVECs were mechanically stimulated (time 0 secs: fine arrow) with a glass pipette. An increase in intracellular Ca2+ is shown by the change in fluorescence intensity in the stimulated cell (time 14 secs). Ca2+ is propagated along a TNT (60 secs: thick arrow) and into the connecting cell (time 106 secs). Unconnected cells (arrowheads) do not respond. Scale bar 50āĪ¼m.
