Figure 1 | Scientific Reports

Figure 1

From: In vivo Molecular Imaging of Glutamate Carboxypeptidase II Expression in Re-endothelialisation after Percutaneous Balloon Denudation in a Rat Model

Figure 1

Increased GCPII-expression in the rat CCA after dilatation with a balloon catheter. (a) Schematic drawing of the dilatation site (yellow) and the cervical ganglia (red and green) used as landmarks. (b) [18F]DCFPyL-PET image five days post-op. The image was tilted (see insert, level a–d) so that the CCA was oriented in the horizontal plane. Red squares indicate position of the VOIs. (c) Blocking experiment with PMPA (23 mg/kg BW), injected together with [18F]DCFPyL. (d) Image of a different rat seven days post-op. in horizontal and transverse view. E: Plotting of VOI ratios (ipsi-/contralateral) over time after dilatation. Blue lines indicate animals that were measured twice. Abbreviations: B: brain; CCA: common carotid artery; ECA: external carotid artery; ICA: internal carotid artery; ICG: inferior cervical ganglion; SCG: superior cervical ganglion; SG: salivary gland; SJ: shoulder joint. SpG: Spinal ganglia. Scale bars: 1 cm.

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