Figure 3 | Scientific Reports

Figure 3

From: Helicobacter pylori-infected C57BL/6 mice with different gastrointestinal microbiota have contrasting gastric pathology, microbial and host immune responses

Figure 3

H. pylori colonization, serum IgG responses to H. pylori infection, and expression of select host genes were compared between Jax and Tac mice. (A) Gastric H. pylori colonization levels that was higher in Jax mice than Tac mice. The numbers on the y axis represent the copies of H. pylori genome expressed per µg murine DNA in the samples. (B) H. pylori-specific IgG2c levels measured with ELISA. (C) H. pylori-specific total IgG and Th2-associated IgG1 levels measured with ELISA. (D) mRNA levels of the target genes in stomach. All the mRNA levels were normalized to the expression of the housekeeping gene Gapdh. The y axes represent the mean fold changes (±standard deviations) of the mRNA levels in reference to uninfected Jax controls. P values: *<0.05. **<0.01, ***<0.001, ****<0.0001. Values indicated by arrows in B and C from H. pylori-infected Tac mice which were H. pylori-negative at 16 WPI.

Back to article page