Table 1 Promotion of distinct KEGG pathways in silico between Jax (in bold) and Tac B6 mice based on their gastric microbial community structures.
Level_1 | Level_2 | Level_3 | Jax: mean rel. freq. (%) | Tac: mean rel. freq. (%) | p-values | p-values (corrected) |
---|---|---|---|---|---|---|
Metabolism | Biosynthesis of Other Secondary Metabolites | Isoquinoline alkaloid biosynthesis | 0.03404 | 0.02201 | 0.00112 | 0.01017 |
Metabolism | Biosynthesis of Other Secondary Metabolites | Novobiocin biosynthesis | 0.09762 | 0.06572 | 0.00417 | 0.02173 |
Metabolism | Biosynthesis of Other Secondary Metabolites | Phenylpropanoid biosynthesis | 0.15779 | 0.102 | 0.00435 | 0.02231 |
Metabolism | Biosynthesis of Other Secondary Metabolites | Tropane, piperidine and pyridine alkaloid biosynthesis | 0.077 | 0.05614 | 0.00847 | 0.03386 |
Organismal Systems | Endocrine System | Adipocytokine signaling pathway | 0.03852 | 0.02368 | 0.00249 | 0.01512 |
Organismal Systems | Endocrine System | Insulin signaling pathway | 0.054 | 0.03361 | 0.01225 | 0.04564 |
Organismal Systems | Endocrine System | Progesterone-mediated oocyte maturation | 0.03291 | 0.02043 | 0.00196 | 0.01338 |
Metabolism | Energy Metabolism | Carbon fixation in photosynthetic organisms | 0.56654 | 0.52247 | 0.00563 | 0.02676 |
Metabolism | Energy Metabolism | Energy metabolism_Unclassified | 0.83812 | 0.66251 | 0.00076 | 0.00829 |
Metabolism | Energy Metabolism | Methane metabolism | 1.20874 | 1.11594 | 0.00767 | 0.03186 |
Metabolism | Energy Metabolism | Oxidative phosphorylation | 1.06587 | 0.96249 | 0.00219 | 0.01438 |
Metabolism | Glycan Biosynthesis and Metabolism | Glycosaminoglycan degradation | 0.06854 | 0.01885 | 0.00124 | 0.01066 |
Metabolism | Glycan Biosynthesis and Metabolism | Glycosphingolipid biosynthesis - ganglio series# | 0.04443 | 0.00841 | 0.00152 | 0.01217 |
Metabolism | Glycan Biosynthesis and Metabolism | Glycosphingolipid biosynthesis - globo series | 0.12934 | 0.06733 | 0.00350 | 0.01913 |
Metabolism | Glycan Biosynthesis and Metabolism | N-Glycan biosynthesis | 0.01782 | 0.00909 | 0.00734 | 0.03166 |
Metabolism | Glycan Biosynthesis and Metabolism | Other glycan degradation | 0.32593 | 0.17931 | 0.01301 | 0.04688 |
Metabolism | Lipid Metabolism | Biosynthesis of unsaturated fatty acids | 0.13432 | 0.17545 | 0.00221 | 0.01420 |
Metabolism | Lipid Metabolism | Fatty acid biosynthesis | 0.37939 | 0.50576 | 0.00002 | 0.00105 |
Metabolism | Lipid Metabolism | Fatty acid metabolism | 0.30793 | 0.3885 | 0.00987 | 0.03901 |
Metabolism | Lipid Metabolism | Lipid biosynthesis proteins | 0.54039 | 0.59328 | 0.00043 | 0.00562 |
Metabolism | Lipid Metabolism | Primary bile acid biosynthesis | 0.04784 | 0.07433 | 0.00583 | 0.02621 |
Metabolism | Lipid Metabolism | Secondary bile acid biosynthesis | 0.04771 | 0.07408 | 0.00581 | 0.02684 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Aminobenzoate degradation | 0.16468 | 0.19258 | 0.00213 | 0.01423 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Benzoate degradation | 0.2908 | 0.36408 | 0.00125 | 0.01049 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Bisphenol degradation | 0.08076 | 0.088 | 0.00316 | 0.01816 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Caprolactam degradation | 0.07281 | 0.11418 | 0.01229 | 0.04530 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Chloroalkane and chloroalkene degradation | 0.20301 | 0.25655 | 0.00013 | 0.00299 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Dioxin degradation | 0.0772 | 0.10618 | 0.01061 | 0.04143 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Drug metabolism - cytochrome P450 | 0.06089 | 0.10521 | 0.00078 | 0.00824 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Metabolism of xenobiotics by cytochrome P450 | 0.05715 | 0.10393 | 0.00047 | 0.00547 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Naphthalene degradation | 0.16058 | 0.21657 | 0.00018 | 0.00360 |
Metabolism | Xenobiotics Biodegradation and Metabolism | Polycyclic aromatic hydrocarbon degradation | 0.09134 | 0.12857 | 0.00028 | 0.00509 |