Figure 1
From: Linking drug target and pathway activation for effective therapy using multi-task learning
Macau factorization model: (a) The drug response (IC50) is computed by 2 latent matrices. Each of them is being sampled by a Gibbs sampler. In presence of additional information (side information), the latent matrix is predicted by a multiplication of a link matrix and the side information matrix. Arrows in this figure indicate the matrix multiplication. (b) By multiplying the 2 link matrices, we obtain the interaction matrix, which is the interaction between the features of the drugs with the features of the cell lines.
