Figure 2
From: Linking drug target and pathway activation for effective therapy using multi-task learning
Tissue specific analysis of interaction matrix. We used target on drug side and pathway activity on cell line side and analyzed all tissues in the GDSC panel with at least 20 samples, and display the targets which have an interaction for at least 1 pathway in the top 5% absolute value. We subset the targets a second time by keeping the top 25 targets with the highest variance across the pathways in term of interactions. Here, we highlight 4 representative tissues: (a) Bone. (b) Brain. (c) Skin. (d) Stomach.
