Table 2 Key metabolites to discriminate serum from rats with a deep vein thrombosis (DVT) from the sham and control groups.

From: Comparison of the serum metabolic signatures based on 1H NMR between patients and a rat model of deep vein thrombosis

No

Metabolites

KEGG IDs

Chemical shifta

DVT vs control

p valuesb

VIPc

1

lipid

NA

0.88(m), 1.27 (m)

ā†‘*

4.05

2

leucine

C00123

0.95 (dd)

ā†‘*

1.65

3

valine

C00183

0.98 (d), 1.04 (d)

ā†‘*

1.28

4

lactate

C00186

1.32 (d), 4.12 (q)

ā†“**

5.18

5

alanine

C00041

1.46 (d)

ā†“**

2.45

6

NAC

NA

2.04 (s)

ā†‘*

1.18

7

OAC

NA

2.14 (s)

ā†‘*

1.16

8

acetoacetate

C00164

2.28 (s)

ā†‘**

1.13

9

pyruvate

C00022

2.37 (s)

ā†‘*

2.16

10

glucose

C00031

3.25 (t), 3.42 (m), 55(dd), 3.72 (m), 3.90 (dd), 5.24(d)

ā†“***

6.97

11

methanol

C00132

3.39 (s)

ā†“***

4.69

  1. aS, singlet; d, double; t, triple; q, quartet; m, multiplet; dd, double doublet. bP-values were derived from two-tailed Studentā€™s t- test: *pā€‰<ā€‰0.05, **pā€‰<ā€‰0.01, ***pā€‰<ā€‰0.001. Metabolites marked with ā†‘ increased compared with the respective group; metabolites marked with ā†“ decreased compared to the respective group. cVariable importance in the projection (VIP) value was obtained from OPLS-DA with a threshold of 1.0. NAC: N-acetylglycoproteins, OAC: O-acetylglycoproteins.
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