Table 5 Pathway analysis results from the different metabolites in serum from patients with a DVT.

From: Comparison of the serum metabolic signatures based on 1H NMR between patients and a rat model of deep vein thrombosis

No.

Pathway name

Total

Hits

p values

log(p)

Holm p

Impact

1

*Synthesis and degradation of ketone bodies

6

3

8.22E-06

11.708

6.58E-06

0.700

2

*Pyruvate metabolism

32

4

8.68E-05

9.3517

6.60E-03

0.420

3

D-Glutamine and D-glutamate metabolism

11

2

0.003113

5.7722

0.22413

0.353

4

Glycine, serine and threonine metabolism

48

3

0.005765

5.1560

0.39775

0.188

5

Methane metabolism

34

3

0.002139

6.1474

0.15829

0.164

6

*Butanoate metabolism

40

3

0.003427

5.6760

0.24334

0.130

7

Phenylalanine metabolism

45

3

0.004801

5.3390

0.33606

0.119

8

*Glycolysis or Gluconeogenesis

31

4

7.63E-05

9.4802

0.00588

0.096

9

Aminoacyl-tRNA biosynthesis

75

6

1.47E-05

11.126

0.00115

0.056

10

Propanoate metabolism

35

4

0.000125

8.991

0.00934

0.043

11

Arginine and proline metabolism

77

4

0.002604

5.9506

0.19012

0.041

12

*Valine, leucine and isoleucine biosynthesis

27

2

0.018427

3.9939

1.00000

0.035

  1. *Represents pathways significantly altered in DVT rats and patients.