Figure 5
Synaptic activity regulates the anterograde soluble transport of ChAT. Schematic showing possible role of a retrograde signaling feedback that regulates the axonal transport of ChAT. The interaction between ChAT and Kinesin-2 is required for the axonal entry of ChAT and its anterograde propagation. Block in the choline uptake at the presynaptic terminal causes loss in acetylcholine synthesis and release. Lack of postsynaptic stimulation might elicit changes in the presynaptic neuron which further impinge on the interaction between Kinesin-2 and ChAT. As a result ChAT entry into the axon and its active transport by Kinesin-2 are impaired.
