Figure 2
Cell-type specific model extraction for Arabidopsis root. (a) Types of tissues (stele) and cell types, i.e. epidermis, cortex, endodermis and lateral root cap. (b) For tissue/cell type-specific transcriptomics data, decoupled models for every single tissue are extracted from an initial generic model. Vertices represent metabolites, lines stand for reactions. Transcriptomics and metabolomics data for the components, i.e., genes and metabolites, are used for model extraction. Colored lines correspond to reactions that are extracted from the initial model. The colors correspond to the respective tissue. (c) The replicates of the initial model are connected to each other via exchange reactions. A multi-tissue model is then extracted based on the corresponding transcriptomics data. The purple colored lines show the reactions connecting the multi-tissue model. The single-tissue specific parts within the multi-tissue model refer the coupled models, and are represented in different colors. Note that the decoupled and coupled models may differ.
