Figure 2
From: A map of the PGC-1α- and NT-PGC-1α-regulated transcriptional network in brown adipose tissue
PGC-1α/NT-PGC-1α chromatin occupancy in brown adipose tissue. (A) Pie chart demonstrating the distribution of features in genome and among PGC-1α/NT-PGC-1α binding peaks. The listed genomic features include promoters (≤ 1 kb; 1 kb to 2 kb; 2 kb to 5 kb upstream of the transcription start sites); downstream elements (≤ 1 kb; 1 kb to 2 kb; 2 kb to 5 kb downstream of the transcription termination sites); gene body (5′ UTR, 3′ UTR, coding exons, and introns); and intergenic regions. (B) An average ChIP-seq signal profile around PGC-1α/NT-PGC-1α binding peaks. The average signal represents the average number of reads across the binding regions per 100 bp interval. (C) PGC-1α/NT-PGC-1α ChIP-seq binding profiles for known target genes (Ucp1, Gyk, Esrra, Pdk4, and Cox7b). Green boxes represent the binding site(s) for PGC-1α and NT-PGC-1α.
