Figure 1 | Scientific Reports

Figure 1

From: C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Figure 1

Selected cyanoenone NRF2 activators and their NQO1 inducer potencies (CD values) in Hepa1c1c7 cells. Chemical structures of: 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO), 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid (CDDO-Im), (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydrophenanthrene-2,6-dicarbonitrile (TBE-31), 9a-ethynyl-3-oxo-9,9a-dihydro-3H-fluorene-2-carbonitrile (MCE-23), and 3-ethynyl-3-methyl-6-oxocyclohexa-1,4-dienecarbonitrile (MCE-1).

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