Figure 6
C151 in KEAP1 is required for the ability of TBE-31 to inhibit the gene expression of IL6 and IL1β in primary murine peritoneal macrophages challenged with LPS. mRNA levels for NQO1 (A), HO-1 (B), IL6 (C) and IL1β (D) in peritoneal macrophages isolated from WT (KEAP1+/+) (n = 7) or KEAP1C151S/C151S (n = 11) mice, that had been treated ex vivo with LPS (1 ng/ml) and/or TBE-31 (10 nM) for 4 h. *p < 0.05.
