Figure 1 | Scientific Reports

Figure 1

From: Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy

Figure 1

Microbiota compositional analysis. Average rarefaction curves (with 95% confidence interval) (panel A) and box plots (panel B) of α-diversity richness (observed OTUs) and biodiversity (Shannon index) estimators are reported for each dataset. The PCoA analysis (for β diversity) was based on the Yue & Clayton measure of dissimilarity (panel C), while the within-group Bray-Curtis average distance is reported in (panel D). Pairwise comparisons (panel E) were performed on the average relative abundances at the phylum, family (only ≥ 0.5%) and species (only ≥ 0.5%) levels for all six datasets (biop_cirr, biop_ctrl, feces_cirr, feces_ctrl, periph_cirr, portal_cirr) and reported as pie charts. All families or species whose mean relative abundance is < 0.5% collectively fall within the ‘Other’ group. Lefse analysis (panel F) was performed on all bacterial species, reporting the most discriminant ones (LDA score > 3.5) in decreasing order for each dataset. P values: *≤0.05, **≤0.01, ***≤0.001.

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