Table 2 Association between FGF23, sKlotho and established predictors and freedom from death, HTx, or assist device implantation during the observation period using uni- and multivariate, sex- and age-adjusted Cox proportional hazards regression analyses.

From: Klotho is upregulated in human cardiomyopathy independently of circulating Klotho levels

 

Univariate model

Multivariate model

Wald

HR

95% CI

P value

Wald

HR

95% CI

P value

lnFGF23 (RU/ml)

18.95

1.998

1.463–2.729

<0.001

4.8

1.714

1.058–2.774

0.028

lnsKlotho (mg/dl)

0.78

0.722

0.352–1.484

0.376

2.17

0.626

0.336–1.167

0.141

lneGFR (ml/min/1.73 m2)

25.65

0.078

0.029–0.210

<0.001

0.28

1.640

0.260–10.396

0.598

lnNT-proBNP (ng/l)

21.35

2.412

1.660–3.504

<0.001

6.50

1.727

1.135–2.626

0.011

LV-EF (%)

3.61

1.025

0.999–1.050

0.057

1.11

1.014

0.988–1.042

0.293

  1. eGFR, estimated glomerular filtration rate; NT-proBNP, N-terminal pro-B-type natriuretic peptide; LV-EF, left ventricular ejection fraction.
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