Table 2 Association analysis of the TNFSF13B BAFF-var in two independent SLE cohorts and meta-analysis.

From: Association of a rare variant of the TNFSF13B gene with susceptibility to Rheumatoid Arthritis and Systemic Lupus Erythematosus

Subgroup (N)

Genotype (N)

MAF (%)

Allele test

A|A

A|GCTGT

GCTGT|GCTGT

P-value

OR [95% CI]a

Spain

Controls (3,200)b

10

249

2941

4.20

  

SLE (1,160)

9

117

1034

5.81

0.001

1.41 [1.14–1.74]

Germany

Controls (470)b

0

19

451

2.02

  

SLE (460)

1

32

427

3.69

0.030

1.86 [1.05–3.28]

Meta-analysis c

Controls (4,403)

SLE (6,218)

    

0.0002

1.46 [1.09–2.32]

  1. Abbreviations: N: Number of individuals; MAF: Minor Allele Frequency; OR: Odds Ratio; CI: Confidence Interval.
  2. aOR for the minor allele.
  3. bHealthy controls were used as reference for RA and SLE patients in Spanish and German subgroups.
  4. cHeterogeneity q value = 0.37, I2 = 0.
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