Figure 4 | Scientific Reports

Figure 4

From: MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

Figure 4

MCC950 treatment improves colitis in 10 week old Winnie. (a) Disease activity index. (b) Comparison of summed inflammation scores between control and treatment Winnie mice. PC, proximal colon, MC, middle colon, DC, Distal Colon. Data are represented as means ± SEM (n = 10 per group) *P < 0.05, **P < 0.01, ***P < 0.001 (one-way ANOVA with Tukey’s post-hoc test). (c–e) Representative Winnie control proximal, middle and distal colon sections stained with hematoxylin and eosin at 100x and 400x. (c) Lamina propria inflammatory cell infiltrates (black arrow). (d) Epithelial surface damage (red arrow), goblet cell loss (black arrow). (e) Crypt abscesses with neutrophils in the lumen and nearly intact epithelium (red arrow) or damaged epithelium and complete crypt loss (blue arrow) and crypt architectural distortion (black arrow). (f–h) Representative MCC950 treated Winnie proximal, middle and distal colon sections stained with hematoxylin and eosin at 100x and 400x.

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