Figure 6 | Scientific Reports

Figure 6

From: MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice

Figure 6

MCC950 suppressed proinflammatory cytokine and chemokine production in colon tissues but not in blood serum. Protein levels of cytokines including (a) IL1α (b) MIP1a (c) IL17 (d) IFNγ (e) TNF-α in explant supernatants (f) IL-1β, IL-1α, MIP1a, IL17, IFNγ, and TNF-α in blood serum were determined by Bio-plex. Data are presented as means ± SEM (n = 3) *P < 0.05, **P < 0.01, ***P < 0.001 (two-tailed Student’s t test).

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