Figure 6

Box and whiskers plots represent the steps in Keasar-Foldit-based pipelines for target T0822-D1. First column represents the 20 models created by the servers at stage 1. Second column represents the 151 server models that are made available by the CASP organizers (stage 2). Keasar selects a subset of 10 server models using MESHI. These models are marked as dots in the third column. Then Khatib selects 5 of those models (marked with triangles). Khatib’s selected models (starting points) are given to the Foldit players. The Foldit players created a wide range of models, some of which were substantially better than the starting points as shown in column 4. However, column 5 shows that the clustering and filtering algorithm did not select those best models. Column 6 shows the clusters after refinement by Seok’s lab. Columns 7–13 represent the final selection by different WeFold groups, which selected either exclusively from the clusters in column 6, or from a combination of these and Zhang’s clusters, or from a combination of all the models shared by various WeFold groups and servers. Green line is the best model submitted to CASP11 for that target considering all the CASP11 groups. Note that the tick labels along the x-axis also show the number of models in each step of the pipeline. Box and whiskers plots for all the other targets attempted by the Keasar-Foldit pipelines and Zhang pipelines are in the Supplementary Materials.