Figure 2

Brown adipose tissue (BAT) volume and activity determined by various thresholds of Hounsfield unit (HU) and Standardized uptake value (SUV) for three study cohorts. BAT volume (A–C), SUVmean (D–F), and SUVpeak (G–I) were determined in young lean adults (A,D,G), young overweight/obese adults (B,E,H), and middle-aged overweight/obese adults (C,F,I). Data are means and standard deviation (n = 10 per cohort). Significant differences between thresholds are indicated by parallel horizontal bars (all P ≤ 0.05). BARCIST 1.0: HU:-190, -10; SUV: Individualized [1.2/(lean body mass/body mass)]; BMI: Body mass index; NA: Not applied. See Table S4 for exact absolute and relative differences between thresholds.