Figure 7

Effects of ODN 2088 on CD45⁺CD11b⁺ cells in the LDH following a mid-thoracic SCI at 8 dpi and 28 dpi. (a) The left panels are scatterplots showing CD45⁺CD11b⁺ cells while the right panel is the graphic representation of CD45⁺CD11b⁺ cell number (Uninjured-vehicle: 595.4 ± 126.3; SCI-vehicle: 1,447 ± 223.7; SCI-2088: 1,490 ± 198.3) and (b) Fluorescent intensity (FI) of CD45⁺ and (c) CD11b⁺ cells obtained from the LDH at 8 dpi. (d) The left panels are scatterplots showing CD45⁺CD11b⁺ cells while the right panel is the graphic representation of CD45⁺CD11b⁺ cell number (Uninjured-vehicle: 567.3 ± 89.4; SCI-vehicle: 1,040.5 ± 53.3; SCI-2088: 1,257.5 ± 80.8) and (e) Fluorescent intensity (FI) of CD45⁺ and (f) CD11b⁺ cells obtained from the LDH at 28 dpi. Dark blue histograms represent the FI of cells obtained from uninjured mice, the red histograms represent the FI of cells obtained from vehicle-treated injured mice, and the light blue histogram represent the FI of cells derived from ODN 2088-treated injured mice. Values are mean ± S.E.M. The number of mice in each group is indicated in parentheses above bars. Significantly different by one-way ANOVA, Tukey post-hoc test, **p < 0.01, ***p < 0.001, ****p < 0.0001.