Figure 1 | Scientific Reports

Figure 1

From: Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein

Figure 1

Domain structure and HRR sequences of HRG. (A) Domain structure of human HRG showing the disulfide bridging arrangement and six putative glycosylation sites. The disulfide bridge between the N2 domain and the fragment which can be released by plasmin-mediated cleavage is highlighted in red. Notably, this fragment contains the entire HRR. (B) Sequence alignment of the HRR of HRG from various mammalian species. The sequence of the 35-residue HRGP330 peptide is highlighted in yellow. Amino acids are coloured according to their chemical properties: hydrophobic (black), acidic (red), basic (blue), hydrophilic (green). Symbols represent conservation of amino acids: fully conserved (*), conservation between groups with strongly similar properties (:) and conservation between groups of less similar properties (.). The sequence for rabbit HRG, which has been recently amended11, corresponds to NCBI reference sequence XP_008264798.1.

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