Figure 3 | Scientific Reports

Figure 3

From: Targeted linked-read sequencing for direct haplotype phasing of maternal DMD alleles: a practical and reliable method for noninvasive prenatal diagnosis

Figure 3

Comparison of recombination event estimation results from proband-based indirect phasing and direct phasing. The line graph represents the read fraction of the mutant allele (HapA) obtained from maternal sequencing data of whole DMD gene. The red horizontal line represents the mean read fraction of the mutant allele (HapA). A value greater than 0.5 indicates that the mutant allele is inherited, and an arrow at the change point indicates the possibility of recombination event. DMD-05 family was the only family with a recombination event predicted by direct haplotype phasing. Only the data from the earliest gestational weeks are displayed above (DMD-01 at 6 weeks; DMD-02 at 9 weeks; DMD-03 at 8 weeks; DMD-04 at 7 weeks; DMD-05 at 8 weeks).

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