Table 1 Clinical characteristics.

From: The Significance of Interstitial Fibrosis on Left Ventricular Function in Hypertensive versus Hypertrophic Cardiomyopathy

 

Control (n = 35)

H-LVH (n = 44)

HCM (n = 81)

P value*

Clinical

  Age (yrs)

52.8 ± 14.8

54.4 ± 15.3

55.4 ± 14.3

0.502

  Male gender (%)

19 (54.3)

33 (75.0)

48 (59.3)

0.197

Risk factors

  Hypertension

0 (0)

44(100.0)

29 (42.0)†

<0.001

  Diabetes

2 (5.7)

6 (13.6)

8 (9.9)

0.676

  Current smoking

0 (0)

7 (15.9)

15 (18.5)

0.022

  Hyperlipidaemia

4 (11.4)

14 (31.8)

16 (19.8)

0.064

  NYHA class III/IV

—

2 (5)

0 (0)

0.122

Vital signs

  Heart rate, beats/min

71.2 ± 13.7

73.4 ± 13.7

69.4 ± 11.0

0.225

  Systolic BP, mmHg

118 (110–125)

150 (131–160)

130 (120–140)†

<0.001

  Diastolic BP, mmHg

74 (70–80)

90 (79–100)

76 (70–80)†

<0.001

Lab findings

  eGFR, ml/min/1.73 m2

115.0 ± 20.8

86.9 ± 33.4

97.9 ± 27.9

<0.001

  Haematocrit, %

42.4 ± 3.5

40.4 ± 5.6

42.2 ± 4.8

0.073

Medications

  β-blocker

7 (20.0)

21 (47.7)

49 (60.5)

<0.001

  ACEI or ARB

0 (0)

31 (70.5)

53 (65.4)

<0.001

  CCB

0 (0)

25 (56.8)

27 (33.3)†

<0.001

  Diuretics

0 (0)

21 (47.7)

11 (13.6)†

<0.001

CMR

 Morphology and Function

  Maximum EDWT, mm

7.8 (6.3–9.4)

13.5 (12.7–16.0)

17.0 (14.5–20.0)†

<0.001

  LV mass, g

100.2 (76–116.8)

180.7 (155.3–229.5)

201.9 (145.7–255.1)

<0.001

  LV mass index, g/m2‡

56.5 (46.8–62.4)

100.6 (84.1–121.8)

115 (85.46–143.19)

0.033

  LVEF, %

65.6 (61.1–70.5)

66.13 (57.6–74.9)

76.1 (65.9–79.3)†

<0.001

  LVEDV, ml

124.7 (104.7–140.6)

142.8 (110.6–183.8)

113.5 (98.1–134.4)†

<0.001

  LVEDV index, ml/m2‡

70.1 (61.5–81.7)

77.2 (64.4–102.2)

63.17 (56.29–76.7)†

0.004

  LVESV, ml

44.0 (35.1–52.7)

44.9 (32.23–67.5)

29.9 (21.05–38.65)†

<0.001

  LVESV index, ml/m2‡

24.8 (18.8–29.4)

25.6 (17.0–38.2)

17.2 (11.8–22.0)†

<0.001

  LV mass/volume ratio

0.81 (0.65–0.97)

1.33 (1.18–1.66)

1.72 (1.33–2.30)†

<0.001

Myocardial Scarring

  Scar

0

15 (34.1)

68 (84.0)†

<0.001

  Scar size, %

0 (0)

0–0.94

2.21–15.10†

<0.001

  1. Values are presented as the mean ± SD, number (%), or median (25th-75th percentile). Numbers in boldface indicate P values < 0.05.
  2. *P value across the 3 groups.
  3. †P < 0.05 between the H-LVH and HCM groups.
  4. ‡Indexed to the body surface area.
  5. ACEI = angiotensin-converting-enzyme inhibitor; ARB = angiotensin II receptor blockers; BP = blood pressure; CCB = calcium channel blockers; CMR = cardiac magnetic resonance; EDWT = end-diastolic wall thickness; eGFR = glomerular filtration rate; HCM = hypertrophic cardiomyopathy; LV = left ventricle; LVEF = left ventricular ejection fraction; LVEDV = left ventricular end diastolic volume; LVESV = left ventricular end systolic volume; and NYHA = New York Heart Association.
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