Table 3 Genotype 1b HCV Replicon Assay for Sofosbuvir. The ratios of EC50 values of the mutant HCV strains relative to that of wild-type HCV strain were shown as mean ± SD.

From: Significance of NS5B Substitutions in Genotype 1b Hepatitis C Virus Evaluated by Bioinformatics Analysis

Amino acid substitution in NS5B region

The Ratios of SOF EC50 values relative to that of wild-type HCV

A207T

0.83 ± 0.23

A218S

1.07 ± 0.24

C316N

0.99 ± 0.23

Q464E

0.87 ± 0.17

A218S/C316N

0.85 ± 0.22

A207T/A218S/C316N/Q464E

1.11 ± 0.04

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