Table 1 Results obtained for the described LC-MS/MS method for determination of OG and TG in rats’ plasma & brain tissue.
From: Repositioning of Omarigliptin as a once-weekly intranasal Anti-parkinsonian Agent
Item | Rats’ plasma | Rats’ brain tissue | ||
|---|---|---|---|---|
OG | TG | OG | TG | |
Regression Eq. | Y = 0.0005 × −0.0124 | Y = 0.0007 × −0.0284 | Y = 0.0005 + 0.0161 | Y = 0.0007 × −0.0081 |
Correlation Co. | 0.9994 | 0.9992 | 0.9980 | 0.9983 |
*LLOQ (ng/mL) | 50 | 50 | 50 | 50 |
*LQC (ng/mL) | 120 | 120 | 120 | 120 |
*MQC (ng/mL) | 1500 | 1500 | 1500 | 1500 |
*HQC (ng/mL) | 2500 | 2500 | 2500 | 2500 |
Accuracy (*RE) | −14.08 to +15.26 | −10.82 to +19.07 | −12.24 to +8.53 | −13.1 to +7.98 |
Precision (*% RSD) | 14.22–14.64 | 13.07–13.73 | 8.62–12.53 | 7.7–14.04 |
*ME | 85.99–88.74 | 90.63–98.55 | 89.44–99.66 | 91.77–100.92 |
ME for IS | 84.54–89.16 | 92.49–94.61 | ||
Recovery % | 87.99–91.03 | 77.36–92.52 | 55.29–89.52 | 58.90–91.55 |
Recovery % for IS | 73.83–87.64 | 55.01–85.02 | ||
Stability studies | R% (84.33–95.09) | R% (85.92–97.42) | R% (70.35–89.96) | R% (86.90–91.55) |
