Figure 5 | Scientific Reports

Figure 5

From: Damage-associated molecular pattern recognition is required for induction of retinal neuroprotective pathways in a sex-dependent manner

Figure 5

Proposed model of stress-induced LIF expression. This model is constructed from our data and previous data published in the literature from our lab and others. Stress, either from acute light damage or inherited mutation, induces the formation of DAMPs, which signal to TLR2 and other receptors on microglia. Microglia then produce an intermediate signal to induce Müller cell stress responses, including LIF expression to protect photoreceptors and slow degeneration. In addition, Müller cells upregulate TLR2 and other PRRs allowing them to directly respond to DAMPs.

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