Figure 1 | Scientific Reports

Figure 1

From: LncRNA expression profiling of BMSCs in osteonecrosis of the femoral head associated with increased adipogenic and decreased osteogenic differentiation

Figure 1

The osteogenic differentiation ability of BMSCs between the SONFH (n = 16) and control groups (n = 16). The SONFH group had weaker ARS (A) and ALP (B) staining (40×) than the control group. (C) The SONFH group showed weaker RUNX2 and Osterix immunohistochemical staining. (D) The proportion of ARS-stained areas quantified in the SONFH group was significantly lower than that of control group at day 7, 10 and 14. (E) The ALP activity of the SONFH group was significantly decreased compared to that of the control group at days 7 and 10. (F) The expression levels of BMP2, OPG and RUNX2 during osteogenic differentiation of BMSCs in the SONFH group were significantly decreased comparing to the control group. All samples were normalized to the expression of GAPDH, and the relative expression levels of each gene were analyzed using the 2−△△Ct method. *P < 0.05, **P < 0.01.

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