Table 1 Characteristics and intra-individual variability in histological normal breast tissue.
From: Intra-individual Gene Expression Variability of Histologically Normal Breast Tissue
All (n = 57) n(col%) | Homogeneous (n = 28) n(col%) | Heterogeneous (n = 29) n(col%) | OR (95% CI) | P a | |
|---|---|---|---|---|---|
Age, year | |||||
≥50 | 37 (64.91) | 21 (75) | 16 (55.17) | 1 | 0.1665 |
<50 | 20 (35.09) | 7 (25) | 13 (44.83) | 2.44 (0.79, 7.51) | |
Menopausal status | |||||
Postmenopausal | 39 (69.64) | 20 (71.43) | 19 (67.86) | 1 | 1 |
Premenopausal | 17 (30.36) | 8 (28.57) | 9 (32.14) | 1.18 (0.38, 3.71) | |
BMI | |||||
Non-obese | 37 (64.91) | 16 (57.14) | 21 (72.41) | 1 | 0.2744 |
Obese | 20 (35.09) | 12 (42.86) | 8 (27.59) | 0.51 (0.17, 1.54) | |
Race | |||||
White | 33 (60.00) | 16 (59.26) | 17 (60.71) | 1 | 1 |
Black | 22 (40.00) | 11 (40.74) | 11 (39.29) | 0.94 (0.32, 2.77) | |
Parity | |||||
Nulliparous | 10 (18.87) | 5 (18.52) | 5 (19.23) | 1 | 1 |
Parous | 43 (81.13) | 22 (81.48) | 21 (80.77) | 0.95 (0.24, 3.78) | |
OC | |||||
No | 9 (16.98) | 4 (14.81) | 5 (19.23) | 1 | 0.7277 |
Yes | 44 (83.02) | 23 (85.19) | 21 (80.77) | 0.73 (0.17, 3.09) | |
HRT | |||||
No | 23 (57.50) | 12 (60.00) | 11 (55.00) | 1 | 1 |
Yes | 17 (42.50) | 8 (40.00) | 9 (45.00) | 1.23 (0.35, 4.31) | |
Tissue source | |||||
Lumpectomy or Mastectomy | 36 (73.47) | 21 (80.77) | 15 (65.22) | 1 | 0.3320 |
Reduction | 13 (26.53) | 5 (19.23) | 8 (34.78) | 2.24 (0.61, 8.21) | |
Adipose densityb, cells/mm2 | |||||
≤median | 27 (47.37) | 11 (39.29) | 16 (55.17) | 1 | 0.2924 |
>median | 30 (52.63) | 17 (60.71) | 13 (44.83) | 0.53 (0.18, 1.51) | |
Epithelium densityb, cells/mm2 | |||||
≤median | 32 (56.14) | 17 (60.71) | 15 (51.72) | 1 | 0.5964 |
>median | 25 (43.86) | 11 (39.29) | 14 (48.28) | 1.44 (0.50, 4.13) | |
Stroma densityb, cells/mm2 | |||||
≤median | 28 (49.12) | 18 (64.29) | 10 (34.48) | 1 | 0.0348 |
>median | 29 (50.88) | 10 (35.71) | 19 (65.52) | 3.42 (1.15, 10.15) | |
Adipose areab, mm2 | |||||
≤median | 32 (56.14) | 14 (50.00) | 18 (62.07) | 1 | 0.4287 |
>median | 25 (43.86) | 14 (50.00) | 11 (37.93) | 0.61 (0.21, 1.75) | |
Epithelium areab, mm2 | |||||
≤median | 22 (38.60) | 9 (32.14) | 13 (44.83) | 1 | 0.4173 |
>median | 35 (61.40) | 19 (67.86) | 16 (55.17) | 0.58 (0.20, 1.72) | |
Stroma areab, mm2 | |||||
≤median | 27 (47.37) | 9 (32.14) | 18 (62.07) | 1 | 0.0343 |
>median | 30 (52.63) | 19 (67.86) | 11 (37.93) | 0.29 (0.10, 0.86) | |
