Figure 4 | Scientific Reports

Figure 4

From: Further dissection of QTLs for salt-induced stroke and identification of candidate genes in the stroke-prone spontaneously hypertensive rat

Figure 4

Expression of three candidate genes in the kidney. Kidneys were collected from rats with [Salt (+)] and without [Salt (−)] salt-loading (1% salt water for 1 week). Quantitative RT-PCR was performed as described previously (ref.28, see also Methods). SHRSPrch1_18 and SHRpch1_18 were abbreviated as Pr1_18 and Rp1_18, respectively. All three genes showed a significantly lower expression in both Pr1_18 and SHR than in Rp1_18 and SHRSP (*), which was consistent with the hypothetical expression pattern (see Results). In addition, a significant difference was observed between SHRSP and Rp1_18 (#) in Cxcl17 without salt-loading. Tukey’s multiple comparison test was employed in the analysis. Samples from five rats of each strain were used. Schematic patterns of genomic composition of the four strains are shown in the bottom of the figure; grey and open boxes indicate the genome from SHRSP and SHR, respectively.

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