Figure 6

Effect of nesfatin-1 on visceromotor response to CRD in NH rats. (A) AWR scores under graded distension pressures. (B) AUC of EMG activity in response to graded distension pressures. Intra-DRN injection of nesfatin-1 in NH rats resulted in significantly increased AWR scores and EMG magnitude at 40, 60, and 80 mmHg distension pressures with the vehicle group. [*p < 0.05, **p < 0.01] (n = 6 for each group).