Figure 3 | Scientific Reports

Figure 3

From: Comparative assessment of Graves’ disease and main extrathyroidal manifestation, Graves’ ophthalmopathy, by non-targeted metabolite profiling of blood and orbital tissue

Figure 3

Overview of the relationship between known immune markers (TRAb and TSI) and predictive metabolites. (A) Variable mapping on loading scatter plot by two-way orthogonal projection to latent structures (O2PLS). Metabolite and known immune markers (TRAb and TSI) are assigned as X and Y variables, respectively. Loading of the markers and GC-TOF/MS datasets was combined to one vector. X-axis and Y-axis indicate the combined vectors, pq(corr) and poso(corr) based predictive components 1 and 2, respectively. The resultant loading plot is set to correlation scale. Distance among variables indicates the level of association. Variables in opposite direction from center present a negative relation. Only metabolite name of biomarker constituent is visualized. Pink and blue ovals indicate positively and negatively associated metabolites with TRAb.

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