Figure 2
From: Muscarinic receptor-induced contractions of the detrusor are impaired in TRPC4 deficient mice
(A) Representative traces showing EFS-evoked contractions (1, 2, 4 & 8 Hz, respectively) in TRPC4−/− detrusor strips before, during the presence of α,β-methylene ATP (10 µM) and during the presence of α,β-methylene ATP plus 4-DAMP (100 nM), respectively. (B) Summary bar charts showing mean amplitude of EFS-evoked contractions in TRPC4−/− detrusor strips before (open bars), during the presence of α,β-methylene ATP (grey bars) and α,β-methylene ATP plus 4-DAMP (black bars). Error bars represent SEM. ** denotes p < 0.01 and *** denotes p < 0.001, respectively.
